文章：

CRISPR在癌症生物学和治疗中的应用

CRISPR in cancer biology and therapy

原文发布日期：2022-02-22

DOI: 10.1038/s41568-022-00441-w

类型: Review Article

开放获取: 否

英文摘要：

Over the past decade, CRISPR has become as much a verb as it is an acronym, transforming biomedical research and providing entirely new approaches for dissecting all facets of cell biology. In cancer research, CRISPR and related tools have offered a window into previously intractable problems in our understanding of cancer genetics, the noncoding genome and tumour heterogeneity, and provided new insights into therapeutic vulnerabilities. Here, we review the progress made in the development of CRISPR systems as a tool to study cancer, and the emerging adaptation of these technologies to improve diagnosis and treatment.

摘要翻译： 

在过去的十年中，CRISPR已从专业术语演变为通用词汇，它不仅改变了生物医学研究格局，更为解析细胞生物学的各个层面提供了全新方法。在癌症研究领域，CRISPR及相关工具为我们理解癌症遗传学、非编码基因组和肿瘤异质性这些曾难以攻克的问题打开了窗口，并为治疗靶点的探索提供了新视角。本文回顾了CRISPR系统作为癌症研究工具的发展历程，并探讨这些技术如何逐步应用于改进癌症诊断与治疗。

原文链接：

CRISPR in cancer biology and therapy