文章：

小肽素相关肽酶对肿瘤微环境的重塑

Remodelling of the tumour microenvironment by the kallikrein-related peptidases

原文发布日期：2022-01-31

DOI: 10.1038/s41568-021-00436-z

类型: Review Article

开放获取: 否

英文摘要：

Kallikrein-related peptidases (KLKs) are critical regulators of the tumour microenvironment. KLKs are proteolytic enzymes regulating multiple functions of bioactive molecules including hormones and growth factors, membrane receptors and the extracellular matrix architecture involved in cancer progression and metastasis. Perturbations of the proteolytic cascade generated by these peptidases, and their downstream signalling actions, underlie tumour emergence or blockade of tumour growth. Recent studies have also revealed their role in tumour immune suppression and resistance to cancer therapy. Here, we present an overview of the complex biology of the KLK family and its context-dependent nature in cancer, and discuss the different therapeutic strategies available to potentially target these proteases.

摘要翻译： 

激肽释放酶相关肽酶（KLKs）是肿瘤微环境的关键调控因子。作为蛋白水解酶，KLKs通过调节生物活性分子（包括激素、生长因子、膜受体）以及参与癌症进展和转移的细胞外基质结构来发挥多重功能。这些肽酶产生的蛋白水解级联反应及其下游信号传导的扰动，是肿瘤发生或抑制肿瘤生长的基础机制。最新研究还揭示了它们在肿瘤免疫抑制和癌症治疗耐药性中的作用。本文概述了KLK家族的复杂生物学特性及其在癌症中情境依赖性的本质，并讨论了可能靶向这些蛋白酶的不同治疗策略。

原文链接：

Remodelling of the tumour microenvironment by the kallikrein-related peptidases