文章：

活性氧在肿瘤发生和发展中的作用

The role of ROS in tumour development and progression

原文发布日期：2022-01-31

DOI: 10.1038/s41568-021-00435-0

类型: Review Article

开放获取: 否

英文摘要：

Eukaryotic cells have developed complex systems to regulate the production and response to reactive oxygen species (ROS). Different ROS control diverse aspects of cell behaviour from signalling to death, and deregulation of ROS production and ROS limitation pathways are common features of cancer cells. ROS also function to modulate the tumour environment, affecting the various stromal cells that provide metabolic support, a blood supply and immune responses to the tumour. Although it is clear that ROS play important roles during tumorigenesis, it has been difficult to reliably predict the effect of ROS modulating therapies. We now understand that the responses to ROS are highly complex and dependent on multiple factors, including the types, levels, localization and persistence of ROS, as well as the origin, environment and stage of the tumours themselves. This increasing understanding of the complexity of ROS in malignancies will be key to unlocking the potential of ROS-targeting therapies for cancer treatment.

摘要翻译： 

真核细胞已发展出复杂的系统来调节活性氧（ROS）的产生与应答。不同的活性氧调控着从细胞信号传导到死亡等多个行为维度，而活性氧生成失调与活性氧清除通路异常已成为癌细胞的普遍特征。活性氧还能调节肿瘤微环境，影响为肿瘤提供代谢支持、血液供应和免疫应答的各种基质细胞。尽管活性氧在肿瘤发生过程中具有重要作用已毋庸置疑，但可靠预测活性氧调节疗法的效果仍非易事。目前我们认识到，细胞对活性氧的反应极其复杂，取决于多种因素：包括活性氧的种类、水平、定位与持续时间，以及肿瘤的来源、微环境和发展阶段。深入理解活性氧在恶性肿瘤中的这种复杂性，将成为释放靶向活性氧疗法在癌症治疗中潜力的关键所在。

原文链接：

The role of ROS in tumour development and progression