文章：

骨转移过程中不断发展的癌症生态位相互作用和治疗靶点

Evolving cancer–niche interactions and therapeutic targets during bone metastasis

原文发布日期：2021-10-05

DOI: 10.1038/s41568-021-00406-5

类型: Review Article

开放获取: 否

英文摘要：

Many cancer types metastasize to bone. This propensity may be a product of genetic traits of the primary tumour in some cancers. Upon arrival, cancer cells establish interactions with various bone-resident cells during the process of colonization. These interactions, to a large degree, dictate cancer cell fates at multiple steps of the metastatic cascade, from single cells to overt metastases. The bone microenvironment may even influence cancer cells to subsequently spread to multiple other organs. Therefore, it is imperative to spatiotemporally delineate the evolving cancer–bone crosstalk during bone colonization. In this Review, we provide a summary of the bone microenvironment and its impact on bone metastasis. On the basis of the microscopic anatomy, we tentatively define a roadmap of the journey of cancer cells through bone relative to various microenvironment components, including the potential of bone to function as a launch pad for secondary metastasis. Finally, we examine common and distinct features of bone metastasis from various cancer types. Our goal is to stimulate future studies leading to the development of a broader scope of potent therapies.

摘要翻译： 

许多癌症类型会转移至骨骼。这种倾向可能是一些癌症中原发肿瘤遗传特性的产物。到达骨骼后，癌细胞在定植过程中与各种骨组织驻留细胞建立相互作用。这些相互作用在很大程度上决定了癌细胞在转移级联过程中多个阶段的命运，从单个细胞到明显转移灶的形成。骨微环境甚至可能影响癌细胞随后向其他多个器官的扩散。因此，必须从时空维度解析骨定植过程中不断演变的癌-骨相互作用。本篇综述中，我们总结了骨微环境及其对骨转移的影响。基于显微解剖结构，我们初步定义了癌细胞在骨骼中相对于各种微环境成分的迁移路径图，包括骨骼作为继发转移跳板的潜力。最后，我们探讨了不同癌症类型骨转移的共性与特性，旨在推动未来研究的发展，从而开发出更广泛的有效疗法。

原文链接：

Evolving cancer–niche interactions and therapeutic targets during bone metastasis