文章：

巴雷特食管到食管癌的演变与进展

Evolution and progression of Barrett’s oesophagus to oesophageal cancer

原文发布日期：2021-09-20

DOI: 10.1038/s41568-021-00400-x

类型: Review Article

开放获取: 否

英文摘要：

Cancer cells are shaped through an evolutionary process of DNA mutation, cell selection and population expansion. Early steps in this process are driven by a set of mutated driver genes and structural alterations to the genome through copy number gains or losses. Oesophageal adenocarcinoma (EAC) and the pre-invasive tissue, Barrett’s oesophagus (BE), provide an ideal example in which to observe and study this evolution. BE displays early genomic instability, specifically in copy number changes that may later be observed in EAC. Furthermore, these early changes result in patterns of progression (that is, ‘born bad’, gradual or catastrophic) that may help to describe the evolution of EAC. As only a small proportion of patients with BE will go on to develop cancer, a better understanding of these patterns and the resulting genomic changes should improve early detection in EAC and may provide clues for the evolution of cancer more broadly.

摘要翻译： 

癌细胞通过DNA突变、细胞选择和群体扩张的进化过程形成。这一过程的早期步骤由一组突变驱动基因和通过拷贝数增加或缺失导致的基因组结构改变所驱动。食管腺癌及其前期组织巴雷特食管为观察和研究这一进化过程提供了理想范例。巴雷特食管表现出早期基因组不稳定性，特别是拷贝数变化，这些变化后续可能在食管腺癌中观察到。此外，这些早期变化会形成进展模式（即“天生恶性型”、“渐进型”或“灾难型”），这些模式可能有助于描述食管腺癌的进化过程。由于仅有少数巴雷特食管患者会最终发展为癌症，更好地理解这些模式及由此产生的基因组变化，将有助于改进食管腺癌的早期检测，并可能为更广泛意义上的癌症进化提供线索。

原文链接：

Evolution and progression of Barrett’s oesophagus to oesophageal cancer