文章：

脑肿瘤微环境中的神经胶质和髓细胞异质性

Glial and myeloid heterogeneity in the brain tumour microenvironment

原文发布日期：2021-09-28

DOI: 10.1038/s41568-021-00397-3

类型: Review Article

开放获取: 否

英文摘要：

Brain cancers carry bleak prognoses, with therapeutic advances helping only a minority of patients over the past decade. The brain tumour microenvironment (TME) is highly immunosuppressive and differs from that of other malignancies as a result of the glial, neural and immune cell populations that constitute it. Until recently, the study of the brain TME was limited by the lack of methods to de-convolute this complex system at the single-cell level. However, novel technical approaches have begun to reveal the immunosuppressive and tumour-promoting properties of distinct glial and myeloid cell populations in the TME, identifying new therapeutic opportunities. Here, we discuss the immune modulatory functions of microglia, monocyte-derived macrophages and astrocytes in brain metastases and glioma, highlighting their disease-associated heterogeneity and drawing from the insights gained by studying these malignancies and other neurological disorders. Lastly, we consider potential approaches for the therapeutic modulation of the brain TME.

摘要翻译： 

脑癌预后黯淡，过去十年的治疗进展仅对少数患者有所帮助。脑肿瘤微环境具有高度免疫抑制性，且因其由胶质细胞、神经元及免疫细胞群体构成而与其他恶性肿瘤的微环境存在差异。直至近期，由于缺乏在单细胞水平解析这一复杂系统的方法，脑肿瘤微环境的研究一直受限。然而，新技术手段已开始揭示肿瘤微环境中不同胶质细胞和髓系细胞群体的免疫抑制及促肿瘤特性，为治疗提供了新机遇。本文旨在探讨小胶质细胞、单核源性巨噬细胞和星形胶质细胞在脑转移瘤和神经胶质瘤中的免疫调节功能，重点阐述其疾病相关异质性，并借鉴通过研究这些恶性肿瘤及其他神经系统疾病所获得的见解。最后，我们将探讨脑肿瘤微环境治疗性调控的潜在途径。

原文链接：

Glial and myeloid heterogeneity in the brain tumour microenvironment