文章：

在治疗抵抗和肥胖背景下的肿瘤脂肪酸代谢

Tumour fatty acid metabolism in the context of therapy resistance and obesity

原文发布日期：2021-08-20

DOI: 10.1038/s41568-021-00388-4

类型: Review Article

开放获取: 否

英文摘要：

Fatty acid metabolism is known to support tumorigenesis and disease progression as well as treatment resistance through enhanced lipid synthesis, storage and catabolism. More recently, the role of membrane fatty acid composition, for example, ratios of saturated, monounsaturated and polyunsaturated fatty acids, in promoting cell survival while limiting lipotoxicity and ferroptosis has been increasingly appreciated. Alongside these insights, it has become clear that tumour cells exhibit plasticity with respect to fatty acid metabolism, responding to extratumoural and systemic metabolic signals, such as obesity and cancer therapeutics, to promote the development of aggressive, treatment-resistant disease. Here, we describe cellular fatty acid metabolic changes that are connected to therapy resistance and contextualize obesity-associated changes in host fatty acid metabolism that likely influence the local tumour microenvironment to further modify cancer cell behaviour while simultaneously creating potential new vulnerabilities.

摘要翻译： 

脂肪酸代谢通过增强脂质合成、储存和分解代谢，已知能够支持肿瘤发生、疾病进展以及治疗抵抗。最近，膜脂肪酸组成（例如饱和、单不饱和和多不饱和脂肪酸的比例）在促进细胞存活、同时限制脂毒性和铁死亡方面的作用日益受到重视。随着这些认识的深入，人们清楚地认识到肿瘤细胞在脂肪酸代谢方面表现出可塑性，能够响应肿瘤外和全身性代谢信号（如肥胖和癌症治疗），从而促进侵袭性、治疗抵抗性疾病的发展。在此，我们描述了与治疗抵抗相关的细胞脂肪酸代谢变化，并阐述了宿主脂肪酸代谢中肥胖相关变化可能影响局部肿瘤微环境，进一步改变癌细胞行为，同时创造潜在新脆弱性的背景。

原文链接：

Tumour fatty acid metabolism in the context of therapy resistance and obesity