文章：

从果蝇的角度看肿瘤与宿主的相互作用

Tumour–host interactions through the lens of Drosophila

原文发布日期：2021-08-13

DOI: 10.1038/s41568-021-00387-5

类型: Review Article

开放获取: 否

英文摘要：

There is a large gap between the deep understanding of mechanisms driving tumour growth and the reasons why patients ultimately die of cancer. It is now appreciated that interactions between the tumour and surrounding non-tumour (sometimes referred to as host) cells play critical roles in mortality as well as tumour progression, but much remains unknown about the underlying molecular mechanisms, especially those that act beyond the tumour microenvironment. Drosophila has a track record of high-impact discoveries about cell-autonomous growth regulation, and is well suited to now probe mysteries of tumour – host interactions. Here, we review current knowledge about how fly tumours interact with microenvironmental stroma, circulating innate immune cells and distant organs to influence disease progression. We also discuss reciprocal regulation between tumours and host physiology, with a particular focus on paraneoplasias. The fly’s simplicity along with the ability to study lethality directly provide an opportunity to shed new light on how cancer actually kills.

摘要翻译： 

对驱动肿瘤生长的机制与患者最终死于癌症的原因之间存在巨大认知差距。目前学界已认识到，肿瘤与周围非肿瘤（有时称为宿主）细胞之间的相互作用在死亡率及肿瘤进展中起着关键作用，但关于其潜在分子机制——尤其是那些在肿瘤微环境之外发挥作用机制——仍存在大量未知。黑腹果蝇在细胞自主性生长调控方面已取得多项重大发现，如今特别适合用于探索肿瘤与宿主相互作用的奥秘。本文综述了当前关于果蝇肿瘤如何与微环境基质、循环先天免疫细胞及远端器官相互作用以影响疾病进展的认知，同时探讨了肿瘤与宿主生理之间的相互调控，特别关注副肿瘤综合征。果蝇模型兼具生物结构简单性和直接研究致死性机制的能力，为揭示癌症实际致死机制提供了新的研究契机。

原文链接：

Tumour–host interactions through the lens of Drosophila