文章：

原发性和转移性肝癌的免疫学和代谢景观

The immunological and metabolic landscape in primary and metastatic liver cancer

原文发布日期：2021-07-29

DOI: 10.1038/s41568-021-00383-9

类型: Review Article

开放获取: 否

英文摘要：

The liver is the sixth most common site of primary cancer in humans, and generally arises in a background of cirrhosis and inflammation. Moreover, the liver is frequently colonized by metastases from cancers of other organs (particularly the colon) because of its anatomical location and organization, as well as its unique metabolic and immunosuppressive environment. In this Review, we discuss how the hepatic microenvironment adapts to pathologies characterized by chronic inflammation and metabolic alterations. We illustrate how these immunological or metabolic changes alter immunosurveillance and thus hinder or promote the development of primary liver cancer. In addition, we describe how inflammatory and metabolic niches affect the spreading of cancer metastases into or within the liver. Finally, we review the current therapeutic options in this context and the resulting challenges that must be surmounted.

摘要翻译： 

肝脏是人类原发性癌症的第六大常见发病部位，通常发生于肝硬化和炎症的病理背景之下。由于其解剖位置与组织结构，以及独特的代谢和免疫抑制环境，肝脏常成为其他器官（特别是结肠）癌症转移的侵袭目标。本篇综述中，我们将探讨肝脏微环境如何适应以慢性炎症和代谢改变为特征的病理状态，阐述这些免疫或代谢变化如何改变免疫监视功能，从而抑制或促进原发性肝癌的发展。此外，我们还将解析炎症与代谢生态位如何影响癌症转移至肝脏或在肝内扩散的进程。最后，我们将评估当前可用的治疗策略及由此亟待攻克的临床挑战。

原文链接：

The immunological and metabolic landscape in primary and metastatic liver cancer