文章：

组织清理在三维空间检查肿瘤的复杂性

Tissue clearing to examine tumour complexity in three dimensions

原文发布日期：2021-07-30

DOI: 10.1038/s41568-021-00382-w

类型: Review Article

开放获取: 否

英文摘要：

The visualization of whole organs and organisms through tissue clearing and fluorescence volumetric imaging has revolutionized the way we look at biological samples. Its application to solid tumours is changing our perception of tumour architecture, revealing signalling networks and cell interactions critical in tumour progression, and provides a powerful new strategy for cancer diagnostics. This Review introduces the latest advances in tissue clearing and three-dimensional imaging, examines the challenges in clearing epithelia — the tissue of origin of most malignancies — and discusses the insights that tissue clearing has brought to cancer research, as well as the prospective applications to experimental and clinical oncology.

摘要翻译： 

通过组织透明化和荧光体积成像技术实现整个器官和生物体的可视化，彻底改变了我们观察生物样本的方式。该技术在实体肿瘤中的应用正改变着我们对肿瘤结构的认知，揭示了肿瘤进展中至关重要的信号网络与细胞相互作用，并为癌症诊断提供了强大的新策略。本综述介绍了组织透明化和三维成像技术的最新进展，探讨了上皮组织（绝大多数恶性肿瘤的起源组织）透明化面临的挑战，并讨论了组织透明化为癌症研究带来的新见解，以及在实验肿瘤学和临床肿瘤学中的潜在应用前景。

原文链接：

Tissue clearing to examine tumour complexity in three dimensions