文章：

白介素在癌症中的作用：从生物学到治疗

Interleukins in cancer: from biology to therapy

原文发布日期：2021-06-03

DOI: 10.1038/s41568-021-00363-z

类型: Review Article

开放获取: 否

英文摘要：

Interleukins and associated cytokines serve as the means of communication for innate and adaptive immune cells as well as non-immune cells and tissues. Thus, interleukins have a critical role in cancer development, progression and control. Interleukins can nurture an environment enabling and favouring cancer growth while simultaneously being essential for a productive tumour-directed immune response. These properties of interleukins can be exploited to improve immunotherapies to promote effectiveness as well as to limit side effects. This Review aims to unravel some of these complex interactions.

摘要翻译： 

白细胞介素及相关细胞因子是先天性和适应性免疫细胞以及非免疫细胞与组织之间的沟通媒介。因此，白细胞介素在癌症的发生、发展和控制中起着关键作用。它们既能营造促进癌症生长的微环境，同时又对产生有效的肿瘤靶向免疫反应至关重要。这些特性可用于改进免疫疗法，既提升治疗效果又限制副作用。本综述旨在揭示这些复杂相互作用的部分机制。

原文链接：

Interleukins in cancer: from biology to therapy