文章：

癌症的全身免疫

Systemic immunity in cancer

原文发布日期：2021-04-09

DOI: 10.1038/s41568-021-00347-z

类型: Review Article

开放获取: 否

英文摘要：

Immunotherapy has revolutionized cancer treatment, but efficacy remains limited in most clinical settings. Cancer is a systemic disease that induces many functional and compositional changes to the immune system as a whole. Immunity is regulated by interactions of diverse cell lineages across tissues. Therefore, an improved understanding of tumour immunology must assess the systemic immune landscape beyond the tumour microenvironment (TME). Importantly, the peripheral immune system is required to drive effective natural and therapeutically induced antitumour immune responses. In fact, emerging evidence suggests that immunotherapy drives new immune responses rather than the reinvigoration of pre-existing immune responses. However, new immune responses in individuals burdened with tumours are compromised even beyond the TME. Herein, we aim to comprehensively outline the current knowledge of systemic immunity in cancer.

摘要翻译： 

免疫疗法革新了癌症治疗，但在多数临床环境中疗效仍然有限。癌症是一种全身性疾病，会引发免疫系统整体功能和组成的多重改变。免疫调控依赖于不同组织间多种细胞谱系的相互作用。因此，要深入理解肿瘤免疫学，必须超越肿瘤微环境（TME）的范畴，从全身免疫景观层面进行评估。重要的是，有效激发天然抗肿瘤免疫反应及治疗诱导的免疫应答都需要外周免疫系统的参与。事实上，新证据表明免疫疗法驱动的是新型免疫反应，而非既有免疫反应的复苏。然而，肿瘤负荷个体中产生新型免疫反应的能力即使在肿瘤微环境之外也处于受损状态。本文旨在全面梳理当前对癌症系统性免疫的认知。

原文链接：

Systemic immunity in cancer