文章：

自噬在肿瘤免疫和治疗中的作用

Autophagy in tumour immunity and therapy

原文发布日期：2021-03-23

DOI: 10.1038/s41568-021-00344-2

类型: Review Article

开放获取: 否

英文摘要：

Autophagy is a regulated mechanism that removes unnecessary or dysfunctional cellular components and recycles metabolic substrates. In response to stress signals in the tumour microenvironment, the autophagy pathway is altered in tumour cells and immune cells — thereby differentially affecting tumour progression, immunity and therapy. In this Review, we summarize our current understanding of the immunologically associated roles and modes of action of the autophagy pathway in cancer progression and therapy, and discuss potential approaches targeting autophagy to enhance antitumour immunity and improve the efficacy of current cancer therapy.

摘要翻译： 

自噬是一种受调控的机制，可清除多余或功能异常的细胞组分并回收代谢底物。在肿瘤微环境应激信号作用下，自噬通路在肿瘤细胞与免疫细胞中发生改变——从而差异化影响肿瘤进展、免疫应答及治疗效果。本文综述了当前对自噬通路在癌症进展与治疗中免疫相关作用及作用模式的理解，并探讨了靶向自噬以增强抗肿瘤免疫、提高现有癌症疗法疗效的潜在途径。

原文链接：

Autophagy in tumour immunity and therapy