文章：

癌症进化中的遗传和非遗传克隆多样性

Genetic and non-genetic clonal diversity in cancer evolution

原文发布日期：2021-03-16

DOI: 10.1038/s41568-021-00336-2

类型: Review Article

开放获取: 否

英文摘要：

The observation and analysis of intra-tumour heterogeneity (ITH), particularly in genomic studies, has advanced our understanding of the evolutionary forces that shape cancer growth and development. However, only a subset of the variation observed in a single tumour will have an impact on cancer evolution, highlighting the need to distinguish between functional and non-functional ITH. Emerging studies highlight a role for the cancer epigenome, transcriptome and immune microenvironment in functional ITH. Here, we consider the importance of both genetic and non-genetic ITH and their role in tumour evolution, and present the rationale for a broad research focus beyond the cancer genome. Systems-biology analytical approaches will be necessary to outline the scale and importance of functional ITH. By allowing a deeper understanding of tumour evolution this will, in time, encourage development of novel therapies and improve outcomes for patients.

摘要翻译： 

对肿瘤内异质性（ITH）的观察与分析，特别是在基因组研究中，增进了我们对影响癌症发生发展的进化动力的理解。然而，单个肿瘤中观察到的变异只有一部分会对癌症进化产生影响，这凸显了区分功能性与非功能性肿瘤内异质性的必要性。新兴研究揭示了癌症表观基因组、转录组和免疫微环境在功能性肿瘤内异质性中的作用。在此，我们探讨遗传与非遗传肿瘤内异质性的重要性及其在肿瘤进化中的作用，并提出了超越癌症基因组的更广泛研究范畴的理论依据。系统生物学分析方法将有助于勾勒功能性肿瘤内异质性的规模与重要性。随着对肿瘤进化认识的深化，这将推动新型疗法的开发并最终改善患者预后。

原文链接：

Genetic and non-genetic clonal diversity in cancer evolution