文章：

代谢竞争：昼夜平衡和肿瘤发生

Metabolic rivalry: circadian homeostasis and tumorigenesis

原文发布日期：2020-09-07

DOI: 10.1038/s41568-020-0291-9

类型: Review Article

开放获取: 否

英文摘要：

Circadian rhythms govern a large array of physiological and metabolic functions. Perturbations of the daily cycle have been linked to elevated risk of developing cancer as well as poor prognosis in patients with cancer. Also, expression of core clock genes or proteins is remarkably attenuated particularly in tumours of a higher stage or that are more aggressive, possibly linking the circadian clock to cellular differentiation. Emerging evidence indicates that metabolic control by the circadian clock underpins specific hallmarks of cancer metabolism. Indeed, to support cell proliferation and biomass production, the clock may direct metabolic processes of cancer cells in concert with non-clock transcription factors to control how nutrients and metabolites are utilized in a time-specific manner. We hypothesize that the metabolic switch between differentiation or stemness of cancer may be coupled to the molecular clockwork. Moreover, circadian rhythms of host organisms appear to dictate tumour growth and proliferation. This Review outlines recent discoveries of the interplay between circadian rhythms, proliferative metabolism and cancer, highlighting potential opportunities in the development of future therapeutic strategies.

摘要翻译： 

昼夜节律调控着大量生理和代谢功能。日常周期的紊乱与癌症发生风险升高及患者预后不良密切相关。此外，核心时钟基因或蛋白的表达在更高分期或更具侵袭性的肿瘤中显著减弱，这可能将生物钟与细胞分化联系起来。新近证据表明，生物钟对代谢的调控支撑着癌症代谢的特定特征。事实上，为支持细胞增殖和生物质生产，生物钟可能与非时钟转录因子协同引导癌细胞的代谢过程，以时间特异性的方式控制营养物质和代谢物的利用。我们假设，癌症分化与干性之间的代谢转换可能与分子时钟结构相关联。此外，宿主生物的昼夜节律似乎决定着肿瘤的生长和增殖。本综述概述了昼夜节律、增殖代谢与癌症之间相互作用的最新发现，为未来治疗策略的开发指明潜在机遇。

原文链接：

Metabolic rivalry: circadian homeostasis and tumorigenesis