文章：

免疫环境和免疫评分对肿瘤预后和治疗效果的影响

The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy

原文发布日期：2020-08-04

DOI: 10.1038/s41568-020-0285-7

类型: Review Article

开放获取: 否

英文摘要：

The international American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) tumour-node-metastasis (TNM) staging system provides the current guidelines for the classification of cancer. However, among patients within the same stage, the clinical outcome can be very different. More recently, a novel definition of cancer has emerged, implicating at all stages a complex and dynamic interaction between tumour cells and the immune system. This has enabled the definition of the immune contexture, representing the pre-existing immune parameters associated with patient survival. Even so, the role of distinct immune cell types in modulating cancer progression is increasingly emerging. An immune-based assay named the ‘Immunoscore’ was defined to quantify the in situ T cell infiltrate and was demonstrated to be superior to the AJCC/UICC TNM classification for patients with colorectal cancer. This Review provides a broad overview of the main immune parameters positively or negatively shaping cancer development, including the Immunoscore, and their prognostic and predictive value. The importance of the immune system in cancer control is demonstrated by the requirement for a pre-existing intratumour adaptive immune response for effective immunotherapies, such as checkpoint inhibitors. Finally, we discuss how the combination of multiple immune parameters, rather than individual ones, might increase prognostic and/or predictive power.

摘要翻译： 

国际美国癌症联合委员会/国际癌症控制联盟（AJCC/UICC）的肿瘤-淋巴结-转移（TNM）分期系统为癌症分类提供了现行指南。然而，在同一分期的患者中，临床结果可能存在显著差异。近年来，出现了一种新的癌症定义，指出在所有阶段肿瘤细胞与免疫系统之间都存在复杂而动态的相互作用。这使得免疫环境得以定义，代表了与患者生存相关的既存免疫参数。即便如此，不同免疫细胞类型在调节癌症进展中的作用正日益凸显。一种名为“免疫评分”的免疫检测方法被定义用于量化原位T细胞浸润，并已被证明在结直肠癌患者中优于AJCC/UICC TNM分期。本综述全面概述了正向或负向影响癌症发展的主要免疫参数（包括免疫评分）及其预后和预测价值。免疫系统在癌症控制中的重要性通过有效免疫疗法（如检查点抑制剂）需要预先存在的肿瘤内适应性免疫反应来证明。最后，我们讨论了多重免疫参数的组合（而非单个参数）如何可能增强预后和/或预测能力。

原文链接：

The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy