文章：

肿瘤微环境中嗜酸性粒细胞的新曙光

A new dawn for eosinophils in the tumour microenvironment

原文发布日期：2020-07-16

DOI: 10.1038/s41568-020-0283-9

类型: Review Article

开放获取: 否

英文摘要：

Eosinophils are evolutionarily conserved, pleotropic cells that display key effector functions in allergic diseases, such as asthma. Nonetheless, eosinophils infiltrate multiple tumours and are equipped to regulate tumour progression either directly by interacting with tumour cells or indirectly by shaping the tumour microenvironment (TME). Eosinophils can readily respond to diverse stimuli and are capable of synthesizing and secreting a large range of molecules, including unique granule proteins that can potentially kill tumour cells. Alternatively, they can secrete pro-angiogenic and matrix-remodelling soluble mediators that could promote tumour growth. Herein, we aim to comprehensively outline basic eosinophil biology that is directly related to their activity in the TME. We discuss the mechanisms of eosinophil homing to the TME and examine their diverse pro-tumorigenic and antitumorigenic functions. Finally, we present emerging data regarding eosinophils as predictive biomarkers and effector cells in immunotherapy, especially in response to immune checkpoint blockade therapy, and highlight outstanding questions for future basic and clinical cancer research.

摘要翻译： 

嗜酸性粒细胞在进化上具有保守性，是多能性细胞，在哮喘等过敏性疾病中发挥关键效应功能。然而，嗜酸性粒细胞可浸润多种肿瘤，并能够通过直接与肿瘤细胞相互作用或通过重塑肿瘤微环境（TME）间接调控肿瘤进展。嗜酸性粒细胞能迅速响应多种刺激，并能合成和分泌大量分子，包括可能杀伤肿瘤细胞的独特颗粒蛋白。此外，它们还能分泌促进血管生成和基质重塑的可溶性介质，从而可能促进肿瘤生长。本文旨在全面概述与嗜酸性粒细胞在TME中活性直接相关的基础生物学特性，探讨其向TME归巢的机制，并考察其多样的促肿瘤生成和抗肿瘤生成功能。最后，我们展示了关于嗜酸性粒细胞作为免疫治疗（特别是免疫检查点阻断疗法）中预测性生物标志物和效应细胞的新兴数据，并提出了未来基础与临床癌症研究中亟待解决的重要问题。

原文链接：

A new dawn for eosinophils in the tumour microenvironment