文章：

中性粒细胞在肿瘤进展和治疗中的多样性和可塑性

Neutrophil diversity and plasticity in tumour progression and therapy

原文发布日期：2020-07-21

DOI: 10.1038/s41568-020-0281-y

类型: Review Article

开放获取: 否

英文摘要：

Neutrophils play a key role in defence against infection and in the activation and regulation of innate and adaptive immunity. In cancer, tumour-associated neutrophils (TANs) have emerged as an important component of the tumour microenvironment. Here, they can exert dual functions. TANs can be part of tumour-promoting inflammation by driving angiogenesis, extracellular matrix remodelling, metastasis and immunosuppression. Conversely, neutrophils can also mediate antitumour responses by direct killing of tumour cells and by participating in cellular networks that mediate antitumour resistance. Neutrophil diversity and plasticity underlie the dual potential of TANs in the tumour microenvironment. Myeloid checkpoints as well as the tumour and tissue contexture shape neutrophil function in response to conventional therapies and immunotherapy. We surmise that neutrophils can provide tools to tailor current immunotherapy strategies and pave the way to myeloid cell-centred therapeutic strategies, which would be complementary to current approaches.

摘要翻译： 

中性粒细胞在防御感染以及激活和调节先天性与适应性免疫中起关键作用。在癌症中，肿瘤相关中性粒细胞（TANs）已成为肿瘤微环境的重要组成部分。它们在肿瘤微环境中可发挥双重功能：一方面可通过驱动血管生成、细胞外基质重塑、转移和免疫抑制成为促肿瘤炎症的组成部分；另一方面也能通过直接杀伤肿瘤细胞及参与介导抗肿瘤抵抗的细胞网络来发挥抗肿瘤作用。中性粒细胞的多样性与可塑性构成了其在肿瘤微环境中双重潜力的基础。髓系检查点以及肿瘤和组织环境塑造了中性粒细胞对常规疗法和免疫疗法的反应功能。我们认为中性粒细胞可为优化现有免疫治疗策略提供工具，并为以髓系细胞为中心的治疗策略铺平道路，这类策略将与现有方法形成互补。

原文链接：

Neutrophil diversity and plasticity in tumour progression and therapy