文章：

RNA修饰在癌症中的作用

Role of RNA modifications in cancer

原文发布日期：2020-04-16

DOI: 10.1038/s41568-020-0253-2

类型: Review Article

开放获取: 否

英文摘要：

Specific chemical modifications of biological molecules are an efficient way of regulating molecular function, and a plethora of downstream signalling pathways are influenced by the modification of DNA and proteins. Many of the enzymes responsible for regulating protein and DNA modifications are targets of current cancer therapies. RNA epitranscriptomics, the study of RNA modifications, is the new frontier of this arena. Despite being known since the 1970s, eukaryotic RNA modifications were mostly identified on transfer RNA and ribosomal RNA until the last decade, when they have been identified and characterized on mRNA and various non-coding RNAs. Increasing evidence suggests that RNA modification pathways are also misregulated in human cancers and may be ideal targets of cancer therapy. In this Review we highlight the RNA epitranscriptomic pathways implicated in cancer, describing their biological functions and their connections to the disease.

摘要翻译： 

生物分子的特定化学修饰是调节分子功能的有效途径，并且大量下游信号通路受到DNA和蛋白质修饰的影响。许多负责调节蛋白质和DNA修饰的酶是当前癌症治疗的靶点。RNA表观转录组学，即RNA修饰的研究，是这一领域的新前沿。尽管自20世纪70年代以来就已为人所知，但直到近十年，真核生物RNA修饰才主要在转运RNA和核糖体RNA上被发现，而现在已在信使RNA和各种非编码RNA上得到识别和表征。越来越多的证据表明，RNA修饰通路在人类癌症中也存在失调，可能是癌症治疗的理想靶点。在本综述中，我们重点介绍了与癌症相关的RNA表观转录组通路，描述了它们的生物学功能及其与疾病的关联。

原文链接：

Role of RNA modifications in cancer