文章：

实体肿瘤劫持组蛋白变异网络

Solid tumours hijack the histone variant network

原文发布日期：2021-02-10

DOI: 10.1038/s41568-020-00330-0

类型: Review Article

开放获取: 否

英文摘要：

Cancer is a complex disease characterized by loss of cellular homeostasis through genetic and epigenetic alterations. Emerging evidence highlights a role for histone variants and their dedicated chaperones in cancer initiation and progression. Histone variants are involved in processes as diverse as maintenance of genome integrity, nuclear architecture and cell identity. On a molecular level, histone variants add a layer of complexity to the dynamic regulation of transcription, DNA replication and repair, and mitotic chromosome segregation. Because these functions are critical to ensure normal proliferation and maintenance of cellular fate, cancer cells are defined by their capacity to subvert them. Hijacking histone variants and their chaperones is emerging as a common means to disrupt homeostasis across a wide range of cancers, particularly solid tumours. Here we discuss histone variants and histone chaperones as tumour-promoting or tumour-suppressive players in the pathogenesis of cancer.

摘要翻译： 

癌症是一种复杂的疾病，其特征是由于遗传和表观遗传变化引起的细胞内稳态丧失。新兴证据表明，历史上的变体及其专门蛋白在癌症发生和进展中发挥着重要作用。历史变体参与了许多不同的过程，包括基因组完整性的维持、核结构以及细胞身份。从分子层面来看，历史变体增加了转录动态调控、DNA复制、修复以及分裂过程中染色体分离的复杂性。由于这些功能对于确保正常增殖和维持细胞状态至关重要，癌细胞通过破坏它们来实现变异。历史变体及其专门蛋白的劫持被视为多种癌症，尤其是实体瘤中广泛破坏内稳态的主要途径。在此文中，我们将讨论在癌症发生过程中作为促癌或抑癌作用的历史变体和相关蛋白。

原文链接：

Solid tumours hijack the histone variant network