文章：

癌症中的基质

The matrix in cancer

原文发布日期：2021-02-15

DOI: 10.1038/s41568-020-00329-7

类型: Review Article

开放获取: 否

英文摘要：

The extracellular matrix is a fundamental, core component of all tissues and organs, and is essential for the existence of multicellular organisms. From the earliest stages of organism development until death, it regulates and fine-tunes every cellular process in the body. In cancer, the extracellular matrix is altered at the biochemical, biomechanical, architectural and topographical levels, and recent years have seen an exponential increase in the study and recognition of the importance of the matrix in solid tumours. Coupled with the advancement of new technologies to study various elements of the matrix and cell–matrix interactions, we are also beginning to see the deployment of matrix-centric, stromal targeting cancer therapies. This Review touches on many of the facets of matrix biology in solid cancers, including breast, pancreatic and lung cancer, with the aim of highlighting some of the emerging interactions of the matrix and influences that the matrix has on tumour onset, progression and metastatic dissemination, before summarizing the ongoing work in the field aimed at developing therapies to co-target the matrix in cancer and cancer metastasis.

摘要翻译： 

细胞外基质是所有组织器官中一个基本的核心组成部分，对多细胞生物的存在至关重要。从生命早期到结束，它调节并精确调整身体中所有细胞的过程。在癌症中，细胞外基质在生物化学特性、生物力学性能、结构和拓扑学等方面发生改变，并且近年来关于实体瘤中基质作用的研究和认识显著增加。伴随着对基质及其细胞-基质相互作用中各要素研究和技术进步的新突破，我们已经看到了基于基质、靶向间质的癌症治疗的铺展。这一综述评述了多种实体癌（乳腺癌、胰腺癌和肺癌）中的矩阵生物学各个方面，旨在突出一些新兴的矩阵与肿瘤发生的互动关系及对肿瘤进展和转移性扩散的影响，并总结当前致力于开发协同靶向基质的癌症治疗的研究工作。

原文链接：

The matrix in cancer