文章：

CAR - T细胞的机制和功能的最新进展和发现

Recent advances and discoveries in the mechanisms and functions of CAR T cells

原文发布日期：2021-01-22

DOI: 10.1038/s41568-020-00323-z

类型: Review Article

开放获取: 否

英文摘要：

This Review discusses the major advances and changes made over the past 3 years to our understanding of chimeric antigen receptor (CAR) T cell efficacy and safety. Recently, the field has gained insight into how various molecular modules of the CAR influence signalling and function. We report on mechanisms of toxicity and resistance as well as novel engineering and pharmaceutical interventions to overcome these challenges. Looking forward, we discuss new targets and indications for CAR T cell therapy expected to reach the clinic in the next 1–2 years. We also consider some new studies that have implications for the future of CAR T cell therapies, including changes to manufacturing, allogeneic products and drug-regulatable CAR T cells.

摘要翻译： 

这篇综述探讨了过去三年来合成抗原受体（CAR）T细胞疗效和安全性的重大进展与变化。最近，该领域通过研究CAR的分子模块如何影响信号传导和功能获得了新的见解。我们报告了毒性及抗药性机制以及克服这些挑战所采用的新工程技术和药物干预措施。展望未来，我们讨论了预计在未来一至两年内进入临床试验阶段的CAR T细胞新适应症和新目标。此外，我们还考虑了一些对CAR T细胞疗法未来发展有重要影响的研究，包括制造方法、异基因产品以及药物调节性 CAR T 细胞。

原文链接：

Recent advances and discoveries in the mechanisms and functions of CAR T cells