文章：

非整倍体作为恶性生长的启动子和抑制子

Aneuploidy as a promoter and suppressor of malignant growth

原文发布日期：2021-01-11

DOI: 10.1038/s41568-020-00321-1

类型: Review Article

开放获取: 否

英文摘要：

Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years, but the connection between chromosomal errors and malignant growth has remained obscure. New evidence emerging from both basic and clinical research has illuminated a complicated relationship: despite its frequency in human tumours, aneuploidy is not a universal driver of cancer development and instead can exert substantial tumour-suppressive effects. The specific consequences of aneuploidy are highly context dependent and are influenced by a cell’s genetic and environmental milieu. In this Review, we discuss the diverse facets of cancer biology that are shaped by aneuploidy, including metastasis, drug resistance and immune recognition, and we highlight aneuploidy’s distinct roles as both a tumour promoter and an anticancer vulnerability.

摘要翻译： 

非整倍体在一百多年前就被确认为肿瘤发生的标志之一，但染色体错误与恶性生长之间的关联始终未明。基础与临床研究的新证据揭示了这一复杂关系：尽管非整倍体在人类肿瘤中普遍存在，它并非癌症发展的必然驱动因素，反而可能产生显著的肿瘤抑制效应。非整倍体的具体后果高度依赖环境背景，并受细胞遗传特性和微环境的影响。本文综述中，我们将探讨非整倍体塑造癌症生物学的多个维度——包括转移、耐药性和免疫识别，并重点阐释非整倍体作为肿瘤促进因子与抗癌弱点的双重角色。

原文链接：

Aneuploidy as a promoter and suppressor of malignant growth