文章：

癌细胞在转移过程中的代谢

The metabolism of cancer cells during metastasis

原文发布日期：2021-01-18

DOI: 10.1038/s41568-020-00320-2

类型: Review Article

开放获取: 否

英文摘要：

Metastasis formation is the major cause of death in most patients with cancer. Despite extensive research, targeting metastatic seeding and colonization is still an unresolved challenge. Only recently, attention has been drawn to the fact that metastasizing cancer cells selectively and dynamically adapt their metabolism at every step during the metastatic cascade. Moreover, many metastases display different metabolic traits compared with the tumours from which they originate, enabling survival and growth in the new environment. Consequently, the stage-dependent metabolic traits may provide therapeutic windows for preventing or reducing metastasis, and targeting the new metabolic traits arising in established metastases may allow their eradication.

摘要翻译： 

转移灶的形成是大多数癌症患者死亡的主要原因。尽管已有大量研究，但针对转移定植和殖民化的靶向治疗仍是尚未解决的难题。近期研究开始关注到，转移性癌细胞在转移 cascade 的每个阶段都会选择性地动态调整其代谢模式。此外，许多转移灶表现出与原发肿瘤不同的代谢特征，这种适应性改变使其能在新环境中存活和生长。因此，阶段特异性代谢特征或将为预防或减少转移提供治疗窗口，而针对已形成转移灶中新出现的代谢特征可能实现病灶的根除。

原文链接：

The metabolism of cancer cells during metastasis