文章：

PKC异构体在癌症中的模棱两可、明确和紧急作用

Equivocal, explicit and emergent actions of PKC isoforms in cancer

原文发布日期：2020-11-11

DOI: 10.1038/s41568-020-00310-4

类型: Review Article

开放获取: 否

英文摘要：

The maturing mutational landscape of cancer genomes, the development and application of clinical interventions and evolving insights into tumour-associated functions reveal unexpected features of the protein kinase C (PKC) family of serine/threonine protein kinases. These advances include recent work showing gain or loss-of-function mutations relating to driver or bystander roles, how conformational constraints and plasticity impact this class of proteins and how emergent cancer-associated properties may offer opportunities for intervention. The profound impact of the tumour microenvironment, reflected in the efficacy of immune checkpoint interventions, further prompts to incorporate PKC family actions and interventions in this ecosystem, informed by insights into the control of stromal and immune cell functions. Drugging PKC isoforms has offered much promise, but when and how is not obvious.

摘要翻译： 

癌症基因组的突变图谱日趋成熟，临床干预措施的开发应用以及对肿瘤相关功能认识的不断深化，共同揭示了丝氨酸/苏氨酸蛋白激酶C家族出人意料的特征。这些进展包括近期研究发现：与驱动基因或旁观者角色相关的功能获得性或丧失性突变，构象约束与可塑性如何影响此类蛋白质，以及新兴的癌症相关特性如何为干预提供契机。肿瘤微环境的深远影响——这已在免疫检查点干预措施的疗效中得到体现——进一步促使我们结合对基质细胞和免疫细胞功能调控的认知，将PKC家族的作用及干预措施纳入这一生态系统进行研究。靶向PKC亚型药物曾展现巨大潜力，但其具体应用时机与方式仍不明确。

原文链接：

Equivocal, explicit and emergent actions of PKC isoforms in cancer