文章：

癌症中的RNA

RNA in cancer

原文发布日期：2020-10-20

DOI: 10.1038/s41568-020-00306-0

类型: Review Article

开放获取: 否

英文摘要：

While the processing of mRNA is essential for gene expression, recent findings have highlighted that RNA processing is systematically altered in cancer. Mutations in RNA splicing factor genes and the shortening of 3′ untranslated regions are widely observed. Moreover, evidence is accumulating that other types of RNAs, including circular RNAs, can contribute to tumorigenesis. In this Review, we highlight how altered processing or activity of coding and non-coding RNAs contributes to cancer. We introduce the regulation of gene expression by coding and non-coding RNA and discuss both established roles (microRNAs and long non-coding RNAs) and emerging roles (selective mRNA processing and circular RNAs) for RNAs, highlighting the potential mechanisms by which these RNA subtypes contribute to cancer. The widespread alteration of coding and non-coding RNA demonstrates that altered RNA biogenesis contributes to multiple hallmarks of cancer.

摘要翻译： 

虽然mRNA加工对于基因表达至关重要，但近期研究强调RNA加工在癌症中会发生系统性改变。RNA剪接因子基因突变和3'非翻译区缩短现象已被广泛观察到。此外，越来越多证据表明环状RNA等其他类型RNA也能促进肿瘤发生。本综述重点阐述编码和非编码RNA的加工过程或活性改变如何影响癌症发展。我们将介绍编码和非编码RNA对基因表达的调控作用，并探讨RNA已明确的功能（微RNA和长链非编码RNA）与新兴作用（选择性mRNA加工和环状RNA），重点揭示这些RNA亚型促进癌症发展的潜在机制。编码与非编码RNA的广泛改变表明，RNA生物合成过程的改变参与了癌症多个标志性特征的形成。

原文链接：

RNA in cancer