文章：

癌症中的神经

Nerves in cancer

原文发布日期：2020-01-23

DOI: 10.1038/s41568-019-0237-2

类型: Review Article

开放获取: 否

英文摘要：

The contribution of nerves to the pathogenesis of malignancies has emerged as an important component of the tumour microenvironment. Recent studies have shown that peripheral nerves (sympathetic, parasympathetic and sensory) interact with tumour and stromal cells to promote the initiation and progression of a variety of solid and haematological malignancies. Furthermore, new evidence suggests that cancers may reactivate nerve-dependent developmental and regenerative processes to promote their growth and survival. Here we review emerging concepts and discuss the therapeutic implications of manipulating nerves and neural signalling for the prevention and treatment of cancer.

摘要翻译： 

神经对恶性肿瘤发病机制的贡献已成为肿瘤微环境的重要组成部分。近期研究表明，外周神经（交感神经、副交感神经和感觉神经）通过与肿瘤及基质细胞相互作用，促进多种实体瘤和血液恶性肿瘤的发生发展。此外，新证据提示癌症可能重新激活神经依赖性发育和再生过程，以促进其生长与存活。本文综述新兴概念，并探讨调控神经及神经信号传导在癌症预防和治疗中的潜在应用价值。

原文链接：

Nerves in cancer