文章：

人类癌症中的CD8+ T细胞状态：来自单细胞分析的见解

CD8+ T cell states in human cancer: insights from single-cell analysis

原文发布日期：2020-02-05

DOI: 10.1038/s41568-019-0235-4

类型: Review Article

开放获取: 否

英文摘要：

The T cell infiltrates that are formed in human cancers are a modifier of natural disease progression and also determine the probability of clinical response to cancer immunotherapies. Recent technological advances that allow the single-cell analysis of phenotypic and transcriptional states have revealed a vast heterogeneity of intratumoural T cell states, both within and between patients, and the observation of this heterogeneity makes it critical to understand the relationship between individual T cell states and therapy response. This Review covers our current knowledge of the T cell states that are present in human tumours and the role that different T cell populations have been hypothesized to play within the tumour microenvironment, with a particular focus on CD8+ T cells. The three key models that are discussed herein are as follows: (1) the dysfunction of T cells in human cancer is associated with a change in T cell functionality rather than inactivity; (2) antigen recognition in the tumour microenvironment is an important driver of T cell dysfunctionality and the presence of dysfunctional T cells can hence be used as a proxy for the presence of a tumour-reactive T cell compartment; (3) a less dysfunctional population of tumour-reactive T cells may be required to drive a durable response to T cell immune checkpoint blockade.

摘要翻译： 

人类癌症中形成的T细胞浸润会改变自然病程，并决定癌症免疫疗法的临床应答概率。近年单细胞表型与转录状态分析技术的突破，揭示了瘤内T细胞状态在患者内部及患者间存在巨大异质性，这种异质性使得理解个体T细胞状态与治疗应答的关系至关重要。本综述阐述了当前关于人类肿瘤中T细胞状态的认知，以及不同T细胞亚群在肿瘤微环境中可能发挥的作用，尤其聚焦CD8+ T细胞。重点探讨三个核心模型：(1) 人类癌症中T细胞功能障碍伴随功能特性改变而非单纯失活；(2) 肿瘤微环境中的抗原识别是驱动T细胞功能障碍的关键因素，因此功能障碍T细胞的存在可作为肿瘤反应性T细胞区室存在的表征；(3) 驱动持久性T细胞免疫检查点阻断应答可能需要功能受损程度更低的肿瘤反应性T细胞群体。

原文链接：

CD8+ T cell states in human cancer: insights from single-cell analysis