文章：

胶质瘤中细胞代谢的改变——可操作的共同依赖目标的新兴景观

Altered cellular metabolism in gliomas — an emerging landscape of actionable co-dependency targets

原文发布日期：2019-12-05

DOI: 10.1038/s41568-019-0226-5

类型: Review Article

开放获取: 否

英文摘要：

Altered cellular metabolism is a hallmark of gliomas. Propelled by a set of recent technological advances, new insights into the molecular mechanisms underlying glioma metabolism are rapidly emerging. In this Review, we focus on the dynamic nature of glioma metabolism and how it is shaped by the interaction between tumour genotype and brain microenvironment. Recent advances integrating metabolomics with genomics are discussed, yielding new insight into the mechanisms that drive glioma pathogenesis. Studies that shed light on interactions between the tumour microenvironment and tumour genotype are highlighted, providing important clues as to how gliomas respond to and adapt to their changing tissue and biochemical contexts. Finally, a road map for the discovery of potential new glioma drug targets is suggested, with the goal of translating these new insights about glioma metabolism into clinical benefits for patients.

摘要翻译： 

细胞代谢的改变是神经胶质瘤的一个标志。在近期一系列技术进步的推动下，对神经胶质瘤代谢分子机制的新见解正在迅速涌现。在本综述中，我们重点关注神经胶质瘤代谢的动态特性，以及它如何受到肿瘤基因型与大脑微环境相互作用的塑造。文中讨论了代谢组学与基因组学相结合的近期进展，为驱动神经胶质瘤发病机制的机制提供了新见解。重点阐述了揭示肿瘤微环境与肿瘤基因型之间相互作用的研究，为神经胶质瘤如何响应和适应其变化的组织和生化环境提供了重要线索。最后，提出了发现潜在神经胶质瘤药物靶点的路线图，旨在将这些关于神经胶质瘤代谢的新见解转化为患者的临床获益。

原文链接：

Altered cellular metabolism in gliomas — an emerging landscape of actionable co-dependency targets