文章：

脑肿瘤的脑免疫学和免疫治疗

Brain immunology and immunotherapy in brain tumours

原文发布日期：2019-12-05

DOI: 10.1038/s41568-019-0224-7

类型: Review Article

开放获取: 否

英文摘要：

Gliomas, the most common malignant primary brain tumours, remain universally lethal. Yet, seminal discoveries in the past 5 years have clarified the anatomy, genetics and function of the immune system within the central nervous system (CNS) and altered the paradigm for successful immunotherapy. The impact of standard therapies on the response to immunotherapy is now better understood, as well. This new knowledge has implications for a broad range of tumours that develop within the CNS. Nevertheless, the requirements for successful therapy remain effective delivery and target specificity, while the dramatic heterogeneity of malignant gliomas at the genetic and immunological levels remains a profound challenge.

摘要翻译： 

胶质瘤作为最常见的恶性原发性脑肿瘤，至今仍无法治愈。然而，过去五年里的重大发现阐明了中枢神经系统内免疫系统的结构、遗传和功能，并改变了成功免疫治疗的范式。目前，人们对标准疗法对免疫治疗反应的影响也有了更深入的理解。这一新认知对中枢神经系统内发生的多种肿瘤都具有重要意义。然而，成功治疗仍需满足有效递送和靶向特异性的要求，而恶性胶质瘤在遗传和免疫水平上的显著异质性仍然是巨大的挑战。

原文链接：

Brain immunology and immunotherapy in brain tumours