文章：

肿瘤转移中的液体及其力学：形成转移

Fluids and their mechanics in tumour transit: shaping metastasis

原文发布日期：2019-11-28

DOI: 10.1038/s41568-019-0221-x

类型: Review Article

开放获取: 否

英文摘要：

Metastasis is a dynamic succession of events involving the dissemination of tumour cells to distant sites within the body, ultimately reducing the survival of patients with cancer. To colonize distant organs and, therefore, systemically disseminate within the organism, cancer cells and associated factors exploit several bodily fluid systems, which provide a natural transportation route. Indeed, the flow mechanics of the blood and lymphatic circulatory systems can be co-opted to improve the efficiency of cancer cell transit from the primary tumour, extravasation and metastatic seeding. Flow rates, vessel size and shear stress can all influence the survival of cancer cells in the circulation and control organotropic seeding patterns. Thus, in addition to using these fluids as a means to travel throughout the body, cancer cells exploit the underlying physical forces within these fluids to successfully seed distant metastases. In this Review, we describe how circulating tumour cells and tumour-associated factors leverage bodily fluids, their underlying forces and imposed stresses during metastasis. As the contribution of bodily fluids and their mechanics raises interesting questions about the biology of the metastatic cascade, an improved understanding of this process might provide a new avenue for targeting cancer cells in transit.

摘要翻译： 

转移是一个动态的连续过程，涉及肿瘤细胞在体内播散至远端部位，最终导致癌症患者生存率降低。为实现远处器官定植及在生物体内的系统性播散，癌细胞及相关因子利用多种体液系统作为天然运输途径。事实上，血液和淋巴循环系统的流动机制可被癌细胞利用，以提升其从原发肿瘤的转运效率、外渗能力及转移定植成功率。流速、血管尺寸和剪切应力均可影响癌细胞在循环系统中的存活率，并控制其向特定器官的定向定植模式。因此，除了利用这些体液作为全身迁移的载体，癌细胞还通过调控体液内部的物理作用力以实现成功的远端转移。本文综述了循环肿瘤细胞及肿瘤相关因子如何利用体液、其内在物理作用力及转移过程中承受的机械应力。鉴于体液及其力学特性对转移级联生物学过程的影响提出了值得探讨的新问题，深入理解这一机制或将为靶向转运过程中的癌细胞提供新途径。

原文链接：

Fluids and their mechanics in tumour transit: shaping metastasis