文章：

补体在癌症中的环境依赖作用

Context-dependent roles of complement in cancer

原文发布日期：2019-10-30

DOI: 10.1038/s41568-019-0210-0

类型: Review Article

开放获取: 否

英文摘要：

The tumour microenvironment (TME) highly influences the growth and spread of tumours, thus impacting the patient’s clinical outcome. In this context, the complement system plays a major and complex role. It may either act to kill antibody-coated tumour cells, support local chronic inflammation or hamper antitumour T cell responses favouring tumour progression. Recent studies demonstrate that these opposing effects are dependent upon the sites of complement activation, the composition of the TME and the tumour cell sensitivity to complement attack. In this Review, we present the evidence that has so far accrued showing a role for complement activation and its effects on cancer control and clinical outcome under different TME contexts. We also include a new analysis of the publicly available transcriptomic data to provide an overview of the prognostic value of complement gene expression in 30 cancer types. We argue that the interplay of complement components within each cancer type is unique, governed by the properties of the tumour cells and the TME. This concept is of critical importance for the design of efficient therapeutic strategies aimed at targeting complement components and their signalling.

摘要翻译： 

肿瘤微环境（TME）深刻影响肿瘤的生长与扩散，进而影响患者的临床结局。在此过程中，补体系统发挥着重要而复杂的作用：它既可清除抗体包被的肿瘤细胞，也可促进局部慢性炎症，或通过抑制抗肿瘤T细胞反应加速肿瘤进展。最新研究表明，这些相反作用取决于补体激活的位点、TME的组成以及肿瘤细胞对补体攻击的敏感性。本文通过系统梳理现有证据，阐释不同TME背景下补体激活对癌症控制及临床结局的影响，并基于公开转录组数据对30种癌症类型中补体基因表达的预后价值进行创新性分析。我们认为，每种癌症类型中补体成分的相互作用具有独特性，这种特性受肿瘤细胞特性与TME共同调控。这一概念对于设计靶向补体成分及其信号通路的高效治疗策略具有关键指导意义。

原文链接：

Context-dependent roles of complement in cancer