文章：

蛋氨酸代谢在健康和癌症：饮食和精准医学的联系

Methionine metabolism in health and cancer: a nexus of diet and precision medicine

原文发布日期：2019-09-12

DOI: 10.1038/s41568-019-0187-8

类型: Review Article

开放获取: 否

英文摘要：

Methionine uptake and metabolism is involved in a host of cellular functions including methylation reactions, redox maintenance, polyamine synthesis and coupling to folate metabolism, thus coordinating nucleotide and redox status. Each of these functions has been shown in many contexts to be relevant for cancer pathogenesis. Intriguingly, the levels of methionine obtained from the diet can have a large effect on cellular methionine metabolism. This establishes a link between nutrition and tumour cell metabolism that may allow for tumour-specific metabolic vulnerabilities that can be influenced by diet. Recently, a number of studies have begun to investigate the molecular and cellular mechanisms that underlie the interaction between nutrition, methionine metabolism and effects on health and cancer.

摘要翻译： 

蛋氨酸的摄取与代谢参与多种细胞功能，包括甲基化反应、氧化还原稳态维持、多胺合成以及与叶酸代谢的耦联，从而协同调控核苷酸代谢和氧化还原状态。这些功能在多种研究中被证实与癌症发病机制相关。值得注意的是，从饮食中获取的蛋氨酸水平会显著影响细胞代谢过程。这建立了营养与肿瘤细胞代谢之间的关联，可能形成可通过饮食干预的肿瘤特异性代谢弱点。近期多项研究开始探索营养、蛋氨酸代谢及其对健康与癌症影响的分子和细胞机制。

原文链接：

Methionine metabolism in health and cancer: a nexus of diet and precision medicine