文章：

揭示衰老：SASP在癌症中的上下文依赖效应

Unmasking senescence: context-dependent effects of SASP in cancer

原文发布日期：2019-06-24

DOI: 10.1038/s41568-019-0156-2

类型: Review Article

开放获取: 否

英文摘要：

Cellular senescence plays a critical role in tumorigenesis. Once thought of as a tissue culture artefact by some researchers, senescence is now a major field of study. Although there are common molecular mechanisms that enforce the growth arrest that characterizes the phenotype, the impact of senescence is varied and can, in some instances, have opposite effects on tumorigenesis. It has become clearer that the cell of origin and the tissue in question dictate the impact of senescence on tumorigenesis. In this Review, we unravel this complexity by focusing on how senescence impacts tumorigenesis when it arises within incipient tumour cells versus stromal cells, and how these roles can change in different stages of disease progression. In addition, we highlight the diversity of the senescent phenotype and its functional output beyond growth arrest: the senescence-associated secretory phenotype (SASP). Fortunately, a number of new genetic and pharmacologic tools have been developed that are now allowing the senescence phenotype to be parsed further.

摘要翻译： 

细胞衰老在肿瘤发生中起着关键作用。曾一度被部分研究者视为组织培养假象的衰老现象，如今已成为重要的研究领域。尽管存在共同的分子机制来维持这种表型特征性的生长停滞，但衰老的影响是多样化的，并且在某些情况下可能对肿瘤发生产生截然相反的作用。愈来愈明确的是，起源细胞及其所在组织决定了衰老对肿瘤发生的影响。本综述将通过聚焦以下方面来解析这一复杂性：衰老在初始肿瘤细胞与基质细胞中产生时如何影响肿瘤发生，以及这些作用在疾病进展的不同阶段如何变化。此外，我们重点探讨了衰老表型及其功能输出的多样性——超越生长停滞的衰老相关分泌表型（SASP）。值得庆幸的是，目前已开发出多种新型遗传学和药理学工具，使得我们能够进一步解析衰老表型。

原文链接：

Unmasking senescence: context-dependent effects of SASP in cancer