文章：

γδ T细胞：具有治疗癌症潜力的多效性免疫效应器

γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer

原文发布日期：2019-06-17

DOI: 10.1038/s41568-019-0153-5

类型: Review Article

开放获取: 否

英文摘要：

The potential of cancer immunotherapy relies on the mobilization of immune cells capable of producing antitumour cytokines and effectively killing tumour cells. These are major attributes of γδ T cells, a lymphoid lineage that is often underestimated despite its major role in tumour immune surveillance, which has been established in a variety of preclinical cancer models. This situation notwithstanding, in particular instances the tumour microenvironment seemingly mobilizes γδ T cells with immunosuppressive or tumour-promoting functions, thus emphasizing the importance of regulating γδ T cell responses in order to realize their translation into effective cancer immunotherapies. In this Review we outline both seminal work and recent advances in our understanding of how γδ T cells participate in tumour immunity and how their functions are regulated in experimental models of cancer. We also discuss the current strategies aimed at maximizing the therapeutic potential of human γδ T cells, on the eve of their exploration in cancer clinical trials that may position them as key players in cancer immunotherapy.

摘要翻译： 

癌症免疫疗法的潜力依赖于能够产生抗肿瘤细胞因子并有效杀伤肿瘤细胞的免疫细胞的动员。γδ T细胞作为淋巴细胞谱系，具备这些主要特性，尽管在多种临床前癌症模型中已确认其在肿瘤免疫监视中的重要作用，但这一细胞类型常被低估。尽管如此，在某些情况下，肿瘤微环境似乎会动员具有免疫抑制或促肿瘤功能的γδ T细胞，这凸显了调控γδ T细胞反应对于实现其向有效癌症免疫疗法转化的必要性。在本篇综述中，我们概述了关于γδ T细胞如何参与肿瘤免疫及其在癌症实验模型中功能调控的奠基性研究和最新进展。同时，在γδ T细胞即将进入癌症临床试验探索之际，我们还讨论了当前旨在最大化人类γδ T细胞治疗潜力的策略，这些试验可能将其确立为癌症免疫疗法中的关键角色。

原文链接：

γδ T cells: pleiotropic immune effectors with therapeutic potential in cancer