文章：

肿瘤免疫的宿主组织决定因素

Host tissue determinants of tumour immunity

原文发布日期：2019-03-12

DOI: 10.1038/s41568-019-0125-9

类型: Review Article

开放获取: 否

英文摘要：

Although common evolutionary principles drive the growth of cancer cells regardless of the tissue of origin, the microenvironment in which tumours arise substantially differs across various organ sites. Recent studies have established that, in addition to cell-intrinsic effects, tumour growth regulation also depends on local cues driven by tissue environmental factors. In this Review, we discuss how tissue-specific determinants might influence tumour development and argue that unravelling the tissue-specific contribution to tumour immunity should help the development of precise immunotherapeutic strategies for patients with cancer.

摘要翻译： 

尽管不论起源组织如何，常见的进化原理驱动着癌细胞的生长，但肿瘤产生的微环境在不同器官部位间存在显著差异。近期研究证实，除了细胞内在效应外，肿瘤生长的调控还取决于组织环境因素驱动的局部信号。在本综述中，我们探讨组织特异性决定因素如何影响肿瘤发展，并阐明解析组织特异性对肿瘤免疫的贡献将有助于为癌症患者制定精准的免疫治疗策略。

原文链接：

Host tissue determinants of tumour immunity