文章：

T细胞特征对血液系统恶性肿瘤CAR-T细胞疗法的影响

Impact of T cell characteristics on CAR-T cell therapy in hematological malignancies

原文发布日期：2024-12-03

DOI: 10.1038/s41408-024-01193-6

类型: Review Article

开放获取: 是

英文摘要：

Chimeric antigen receptor (CAR) T-cell therapy has revolutionized the treatment paradigms for hematological malignancies. However, more than half of these patients cannot achieve sustainable tumor control, partially due to the inadequate potency of CAR-T cells in eradicating tumor cells. T cells are crucial components of the anti-tumor immune response, and multiple intrinsic T-cell features significantly influence the outcomes of CAR-T cell therapy. Herein, we review progressing research on T-cell characteristics that impact the effectiveness of CAR-T cells, including T-cell exhaustion, memory subsets, senescence, regulatory T-cells, the CD4+ to CD8+ T-cell ratio, metabolism, and the T-cell receptor repertoire. With comprehensive insight into the biological processes underlying successful CAR-T cell therapy, we will further refine the applications of these novel therapeutic modalities, and enhance their efficacy and safety for patients.
 

摘要翻译： 

嵌合抗原受体（CAR）T细胞疗法已经彻底改变了血液系统恶性肿瘤的治疗范式。然而，超过半数患者无法实现持续的肿瘤控制，部分原因在于CAR-T细胞清除肿瘤细胞的能力不足。T细胞是抗肿瘤免疫应答的关键组成部分，其多种内在特性显著影响着CAR-T细胞疗法的疗效。本文回顾了影响CAR-T细胞有效性的T细胞特征相关研究进展，包括T细胞耗竭、记忆亚群、衰老、调节性T细胞、CD4+与CD8+ T细胞比例、代谢状态以及T细胞受体库。通过深入理解成功CAR-T细胞治疗背后的生物学过程，我们将进一步优化这类新型治疗模式的应用，并提升其对患者的疗效与安全性。

原文链接：

Impact of T cell characteristics on CAR-T cell therapy in hematological malignancies