文章：

中性粒细胞与淋巴细胞比值作为真性红细胞增多症死亡预后的预测指标：一项前瞻性队列分析

Neutrophil-to-lymphocyte ratio as a prognostic indicator of mortality in Polycythemia Vera: insights from a prospective cohort analysis

原文发布日期：2024-11-06

DOI: 10.1038/s41408-024-01176-7

类型: Article

开放获取: 是

英文摘要：

We analyzed the neutrophil-to-lymphocyte ratio (NLR) in 1508 patients with PV and found that those with an NLR ≥ 5 were generally older, had a longer disease history, and had higher cardiovascular risk factors, more arterial thrombosis, and more aggressive blood counts, indicating a more proliferative disease. NLR was an accurate predictor of mortality, with patients with NLR ≥ 5 having significantly worse overall survival and more than twice the mortality rate compared to those with NLR < 5. Multivariable models confirmed that increasing age, previous venous thrombosis and NLR ≥ 5 were strong predictors of death, further influenced by cardiovascular risk factors. We examined the interaction between NLR and the number of cardiovascular risk factors and found a progressive trend of increased mortality risk for NLR values ≥ 5 in addition to the presence of more than one risk factor. In conclusion, patients with NLR ≥ 5 require careful monitoring and management of cardiovascular risk factors because they increase mortality when associated with progressive levels of NLR.
 

摘要翻译： 

我们对1508例真性红细胞增多症患者的中性粒细胞-淋巴细胞比值进行分析，发现NLR≥5的患者通常年龄更大、病程更长，具有更高的心血管风险因素、更多动脉血栓事件及更具侵袭性的血液学指标，提示疾病增殖性更强。NLR是死亡率的准确预测指标：NLR≥5的患者总生存期显著更差，死亡率较NLR<5组高出两倍以上。多变量模型证实，年龄增长、既往静脉血栓史及NLR≥5是死亡的强预测因子，且受心血管风险因素进一步影响。通过考察NLR与心血管风险因素数量的交互作用，发现当NLR≥5且合并超过一个风险因素时，死亡风险呈进行性上升趋势。综上所述，NLR≥5的患者需要严格监测并管理心血管风险因素，因为这些因素会随着NLR水平升高而加剧死亡风险。

原文链接：

Neutrophil-to-lymphocyte ratio as a prognostic indicator of mortality in Polycythemia Vera: insights from a prospective cohort analysis