文章：

探讨多发性骨髓瘤患者的稳态负荷、社区社会经济地位、症状负担与死亡率之间的关系

Examining allostatic load, neighborhood socioeconomic status, symptom burden and mortality in multiple myeloma patients

原文发布日期：2022-04-01

DOI: 10.1038/s41408-022-00648-y

类型: Article

开放获取: 是

英文摘要：

The objective of this study is to examine the association between neighborhood socioeconomic status (nSES) and baseline allostatic load (AL) and clinical trial endpoints in patients enrolled in the E1A11 therapeutic trial in multiple myeloma (MM). Study endpoints were symptom burden (pain, fatigue, and bother) at baseline and 5.5 months, non-completion of induction therapy, overall survival (OS) and progression-free survival (PFS). Multivariable logistic and Cox regression examined associations between nSES, AL and patient outcomes. A 1-unit increase in baseline AL was associated with greater odds of high fatigue at baseline (adjusted OR [95% CI] = 1.21 [1.08–1.36]) and a worse OS (adjusted hazard ratio, [95% CI] = 1.21 [1.06–1.37]). High nSES was associated with worse baseline bother (middle OR = 4.22 [1.11–16.09] and high 4.49 [1.16–17.43]) compared to low nSES. There was no association between AL or nSES and symptom burden at 5.5 months, non-completion of induction therapy or PFS. Additionally, there was no association between nSES and OS. AL may have utility as a predictive marker for OS among patients with MM and may allow individualization of treatment. Future studies should standardize and validate AL patients with MM.
 

摘要翻译： 

本研究旨在探讨社区社会经济地位与多发性骨髓瘤E1A11治疗试验患者的基线生理负荷及临床试验终点之间的关系。研究终点包括基线和5.5个月时的症状负担、诱导治疗未完成情况、总生存期和无进展生存期。通过多变量逻辑回归和Cox回归分析社区社会经济地位、生理负荷与患者结局的关联性。基线生理负荷每增加1个单位，基线期重度疲劳的发生概率更高，且总生存期更差。与低社区社会经济地位相比，高社区社会经济地位与更严重的基线困扰相关。生理负荷或社区社会经济地位与5.5个月时的症状负担、诱导治疗未完成情况或无进展生存期无显著关联。此外，社区社会经济地位与总生存期也无显著关联。生理负荷可能作为多发性骨髓瘤患者总生存期的预测标志物，并有助于实现个体化治疗。未来研究应对多发性骨髓瘤患者的生理负荷指标进行标准化和验证。

原文链接：

Examining allostatic load, neighborhood socioeconomic status, symptom burden and mortality in multiple myeloma patients