文章：

基于全球数据网络探讨COVID-19对多发性骨髓瘤患者的影响

Impact of COVID-19 in patients with multiple myeloma based on a global data network

原文发布日期：2021-12-10

DOI: 10.1038/s41408-021-00588-z

类型: Article

开放获取: 是

英文摘要：

The COVID-19 pandemic has represented a major cause of morbidity/mortality worldwide, overstressing health systems. Multiple myeloma (MM) patients show an increased risk for infections and they are expected to be particularly vulnerable to SARS-CoV-2 infection. Here we have obtained a comprehensive picture of the impact of COVID-19 in MM patients on a local and a global scale using a federated data research network (TriNetX) that provided access to Electronic Medical Records (EMR) from Health Care Organizations (HCO) all over the world. Through propensity score matched analyses we found that the number of new diagnoses of MM was reduced in 2020 compared to 2019 (RR 0.86, 95%CI 0.76–0.96) and the survival of newly diagnosed MM cases decreased similarly (HR 0.61, 0.38–0.81). MM patients showed higher risk of SARS-CoV-2 infection (RR 2.09, 1.58–2.76) and a higher excess mortality in 2020 (difference in excess mortality 9%, 4.4–13.2) than non-MM patients. By interrogating large EMR datasets from HCO in Europe and globally, we confirmed that MM patients have been more severely impacted by COVID-19 pandemic than non-MM patients. This study highlights the necessity of extending preventive measures worlwide to protect vulnerable patients from SARS-CoV-2 infection by promoting social distancing and an intensive vaccination strategies.
 

摘要翻译： 

COVID-19大流行已成为全球范围内导致发病率/死亡率上升的主要原因，给医疗卫生系统带来巨大压力。多发性骨髓瘤（MM）患者本就存在较高的感染风险，预计其对SARS-CoV-2感染尤为脆弱。本研究通过联合数据研究网络（TriNetX）获取全球各地医疗机构的电子病历数据，全面分析了COVID-19对MM患者在局部及全球范围的影响。通过倾向评分匹配分析发现，与2019年相比，2020年新诊断MM病例数有所减少（相对风险0.86，95%置信区间0.76–0.96），新确诊MM患者的生存率也呈相似下降趋势（风险比0.61，0.38–0.81）。与非MM患者相比，MM患者感染SARS-CoV-2的风险更高（相对风险2.09，1.58–2.76），且2020年超额死亡率增幅更显著（超额死亡率差异为9%，4.4–13.2）。通过对欧洲及全球医疗机构大型电子病历数据的分析，我们证实COVID-19大流行对MM患者的影响程度远超非MM患者。本研究强调，有必要在全球范围内推广保持社交距离和强化疫苗接种策略等预防措施，以保护易感患者免受SARS-CoV-2感染。

原文链接：

Impact of COVID-19 in patients with multiple myeloma based on a global data network