文章：

社会经济匮乏对现代急性髓系白血病管理的长期阴影：是时候揭开挑战了

The long shadow of socioeconomic deprivation over the modern management of acute myeloid leukemia: time to unravel the challenges

原文发布日期：2021-08-06

DOI: 10.1038/s41408-021-00533-0

类型: Review Article

开放获取: 是

英文摘要：

Biological and non-biological variables unrelated to acute myeloid leukemia (AML) preclude standard therapy in many settings, with “real world” patients under-represented in clinical trials and prognostic models. Here, using a case-based format, we illustrate the impact that socioeconomic and anthropogeographical constraints can have on optimally managing AML in 4 different healthcare systems. The granular details provided, emphasize the need for the development and targeting of socioeconomic interventions that are commensurate with the changing landscape of AML therapeutics, in order to avoid worsening the disparity in outcomes between patients with biologically similar disease.
 

摘要翻译： 

与急性髓系白血病（AML）无关的生物及非生物变量常使标准治疗方案无法实施，而临床实验和预后模型往往未能充分体现“现实世界”中患者的多样性。本文采用病例分析形式，通过四种不同医疗体系的实例，阐明社会经济与人口地理限制如何影响AML的优化治疗。所提供的详细细节强调：为适应不断演变的AML治疗格局，必须制定并实施相应的社会经济学干预措施，从而避免生物学特征相似的患者之间出现日益加剧的疗效差异。

原文链接：

The long shadow of socioeconomic deprivation over the modern management of acute myeloid leukemia: time to unravel the challenges