文章：

弥漫大B细胞淋巴瘤患者在接受自体干细胞移植时出现低镁血症与移植失败风险增加相关

Hypomagnesemia at the time of autologous stem cell transplantation for patients with diffuse large B-cell lymphoma is associated with an increased risk of failure

原文发布日期：2021-03-26

DOI: 10.1038/s41408-021-00452-0

类型: Article

开放获取: 是

英文摘要：

Magnesium is an essential element that is involved in critical metabolic pathways. A diet deficient in magnesium is associated with an increased risk of developing cancer. Few studies have reported whether a serum magnesium level below the reference range (RR) is associated with prognosis in patients with diffuse large B cell lymphoma (DLBCL). Using a retrospective approach in DLBCL patients undergoing autologous stem cell transplant (AHSCT), we evaluated the association of hypomagnesemia with survival. Totally, 581 patients eligible for AHSCT with a serum magnesium level during the immediate pre-transplant period were identified and 14.1% (82/581) had hypomagnesemia. Hypomagnesemia was associated with an inferior event-free (EFS) and overall survival (OS) compared to patients with a serum magnesium level within RR; median EFS: 3.9 years (95% CI: 1.63–8.98 years) versus 6.29 years (95% CI: 4.73–8.95 years) with HR 1.63 (95% CI: 1.09–2.43, p = 0.017) for EFS, and median OS: 7.3 years (95% CI: 2.91—upper limit not estimable) versus 9.7 years (95% CI: 6.92–12.3 years) with HR 1.90 (95% CI: 1.22–2.96, p = 0.005) for OS months 0–12, respectively. These findings suggest a potentially actionable prognostic factor for patients with DLBCL undergoing AHSCT.
 

摘要翻译： 

镁是一种参与关键代谢途径的必需元素。饮食中镁缺乏与癌症发生风险增加相关。目前鲜有研究报道血清镁水平低于参考范围是否与弥漫性大B细胞淋巴瘤患者的预后相关。我们通过回顾性研究方法，在接受自体干细胞移植的弥漫性大B细胞淋巴瘤患者中评估了低镁血症与生存期的关联。共纳入581例符合自体干细胞移植条件且移植前即刻检测了血清镁水平的患者，其中14.1%（82/581）存在低镁血症。与血清镁水平在参考范围内的患者相比，低镁血症患者的无事件生存期和总生存期均较差：中位无事件生存期为3.9年（95% CI：1.63–8.98年）对比6.29年（95% CI：4.73–8.95年），风险比为1.63（95% CI：1.09–2.43，p=0.017）；移植后0-12个月的中位总生存期为7.3年（95% CI：2.91—上限无法估计）对比9.7年（95% CI：6.92–12.3年），风险比为1.90（95% CI：1.22–2.96，p=0.005）。这些发现提示，对于接受自体干细胞移植的弥漫性大B细胞淋巴瘤患者，低镁血症可能是一个具有潜在干预价值的预后因素。

原文链接：

Hypomagnesemia at the time of autologous stem cell transplantation for patients with diffuse large B-cell lymphoma is associated with an increased risk of failure