文章：

21世纪初常见血液系统恶性肿瘤诊断后的长期生存变化

Changes in long term survival after diagnosis with common hematologic malignancies in the early 21st century

原文发布日期：2020-05-13

DOI: 10.1038/s41408-020-0323-4

类型: Article

开放获取: 是

英文摘要：

Five-year survival has increased for many hematologic malignancies in the 21st century. However, whether this has translated into greater long-term survival is unknown. Here, we examine 10- and 20-year survival for patients with multiple myeloma (MM), acute lymphoblastic leukemia (ALL), acute myeloblastic leukemia (AML), chronic lymphoid leukemia (CLL), chronic myeloid leukemia (CML), non-Hodgkin lymphoma (NHL), and Hodgkin lymphoma (HL). Data were extracted from the Surveillance, Epidemiology, and End Results-9 database. Patients age 15+ with the above malignancies were included. The newly developed boomerang method was used to examine 10- and 20-year relative survival (RS) for patients in 2002–2006 and 2012–16. Ten and 20-year RS increased for each malignancy examined, with increases ranging from +4.4% units for 20-year RS for AML to +23.1% units for 10-year RS for CML. Ten year RS was >50% in 2012–16 for patients with CLL, CML, HL, NHL, and DLBCL, at 77.1%, 62.1%, 63.9%, 64.5%, and 63.0%, respectively. Survival dropped between 10 and 20 years after diagnosis for most malignancies. Long-term survival is increasing for common hematologic malignancies, but late mortality is an ongoing issue. Further study of long-term outcomes in curable malignancies to determine the reason for these later decreases in survival is indicated.
 

摘要翻译： 

21世纪以来，许多血液系统恶性肿瘤的五年生存率有所提高。然而，这是否转化为更高的长期生存率尚不清楚。在此，我们研究了多发性骨髓瘤（MM）、急性淋巴细胞白血病（ALL）、急性髓系白血病（AML）、慢性淋巴细胞白血病（CLL）、慢性髓系白血病（CML）、非霍奇金淋巴瘤（NHL）和霍奇金淋巴瘤（HL）患者的10年和20年生存率。数据提取自监测、流行病学和最终结果-9数据库。纳入年龄在15岁及以上的上述恶性肿瘤患者。使用新开发的boomerang方法检查了2002-2006年和2012-2016年患者的10年和20年相对生存率（RS）。每种所检查恶性肿瘤的10年和20年相对生存率均有所提高，增幅范围从AML的20年相对生存率增加4.4个百分点到CML的10年相对生存率增加23.1个百分点。在2012-2016年，CLL、CML、HL、NHL和DLBCL患者的10年相对生存率超过50%，分别为77.1%、62.1%、63.9%、64.5%和63.0%。对于大多数恶性肿瘤，诊断后10年至20年间生存率下降。常见血液系统恶性肿瘤的长期生存率正在提高，但晚期死亡率仍然是一个持续存在的问题。有必要对可治愈恶性肿瘤的长期结局进行进一步研究，以确定这些后期生存率下降的原因。

原文链接：

Changes in long term survival after diagnosis with common hematologic malignancies in the early 21st century