文章：

滤泡性淋巴瘤患者治疗、反应及结局变化模式四十年单中心经验

Patterns of change in treatment, response, and outcome in patients with follicular lymphoma over the last four decades: a single-center experience

原文发布日期：2020-03-05

DOI: 10.1038/s41408-020-0299-0

类型: Article

开放获取: 是

英文摘要：

Although the introduction of immunotherapy has improved outcomes for follicular lymphoma (FL) patients, histological transformation (HT) and early relapse still confer a poor prognosis. We sought to describe the patterns of change in treatment, response, and outcome of FL patients at our institution over the last four decades. Seven hundred and twenty-seven patients (389 F/338 M; median age, 57 years) consecutively diagnosed with grade 1-3a FL between 1980 and 2017, categorized into four decades according to the time of diagnosis, constituted the study population. Clinical characteristics, treatment, response, absolute and relative survival, HT, second malignancies (SM), and causes of death were assessed. Median OS for the entire cohort was 17.6 years. From decade 1 to 4, there was an increase in the complete response rate (48 to 70%), progression-free survival (40 to 56% at 5 years), OS (77 to 86% at 5 years), and relative survival ratio (0.83 to 0.94 at 5 years), with no significant differences in the risk of HT or SM. Lymphoma remained the most common cause of death in all four decades. These findings illustrate the overall improvement in outcome for FL patients, but support the need for further research into risk stratification and management.
 

摘要翻译： 

尽管免疫疗法的引入改善了滤泡性淋巴瘤（FL）患者的预后，但组织学转化（HT）和早期复发仍导致其不良预后。我们旨在描述过去四十年来本院FL患者治疗、反应及结局的变化模式。研究纳入了1980年至2017年间连续诊断为1-3a级FL的727例患者（女性389例/男性338例；中位年龄57岁），根据诊断时间分为四个十年期进行研究。评估内容包括临床特征、治疗方案、治疗反应、绝对与相对生存率、HT、第二恶性肿瘤（SM）及死亡原因。整个队列的中位总生存期为17.6年。从第一个十年期到第四个十年期，完全缓解率（48%升至70%）、5年无进展生存率（40%升至56%）、5年总生存率（77%升至86%）及5年相对生存比（0.83升至0.94）均呈现增长，而HT或SM风险无显著差异。在所有四个十年期中，淋巴瘤始终是最常见的死亡原因。这些发现说明了FL患者预后的整体改善，但支持了对风险分层管理和治疗策略进一步研究的必要性。

原文链接：

Patterns of change in treatment, response, and outcome in patients with follicular lymphoma over the last four decades: a single-center experience