文章：

多发性骨髓瘤合并SARS-CoV-2感染：住院死亡患者的临床特征与预后因素

Multiple myeloma and SARS-CoV-2 infection: clinical characteristics and prognostic factors of inpatient mortality

原文发布日期：2020-10-19

DOI: 10.1038/s41408-020-00372-5

类型: Article

开放获取: 是

英文摘要：

There is limited information on the characteristics, prognostic factors, and outcomes of patients with multiple myeloma (MM) hospitalized with COVID-19. This retrospective case series investigated 167 patients reported from 73 hospitals within the Spanish Myeloma Collaborative Group network in March and April, 2020. Outcomes were compared with 167 randomly selected, contemporary, age-/sex-matched noncancer patients with COVID-19 admitted at six participating hospitals. Among MM and noncancer patients, median age was 71 years, and 57% of patients were male; 75 and 77% of patients, respectively, had at least one comorbidity. COVID-19 clinical severity was moderate–severe in 77 and 89% of patients and critical in 8 and 4%, respectively. Supplemental oxygen was required by 47 and 55% of MM and noncancer patients, respectively, and 21%/9% vs 8%/6% required noninvasive/invasive ventilation. Inpatient mortality was 34 and 23% in MM and noncancer patients, respectively. Among MM patients, inpatient mortality was 41% in males, 42% in patients aged >65 years, 49% in patients with active/progressive MM at hospitalization, and 59% in patients with comorbid renal disease at hospitalization, which were independent prognostic factors on adjusted multivariate analysis. This case series demonstrates the increased risk and identifies predictors of inpatient mortality among MM patients hospitalized with COVID-19.
 

摘要翻译： 

关于多发性骨髓瘤（MM）患者因COVID-19住院的特征、预后因素及临床结局的相关信息有限。本回顾性病例系列研究调查了2020年3月至4月期间西班牙骨髓瘤协作组网络内73家医院上报的167例患者，并将其与六家参与医院随机选取的167例同期年龄/性别匹配的非癌症COVID-19住院患者进行对比。两组患者中位年龄均为71岁，男性占57%；分别有75%和77%的患者至少存在一种合并症。COVID-19临床严重程度在中度至重度的比例分别为77%和89%，危重症比例分别为8%和4%。多发性骨髓瘤组与非癌症组分别有47%和55%需要辅助供氧，21%/9% versus 8%/6%需要无创/有创通气。住院死亡率在多发性骨髓瘤组和非癌症组分别为34%和23%。在多发性骨髓瘤患者中，男性住院死亡率为41%，年龄＞65岁者为42%，入院时存在活动性/进展性多发性骨髓瘤者为49%，合并肾脏疾病者为59%；经校正多变量分析显示这些均为独立预后因素。本病例系列研究证实了多发性骨髓瘤合并COVID-19住院患者的死亡风险增高，并明确了其住院死亡率的预测因素。

原文链接：

Multiple myeloma and SARS-CoV-2 infection: clinical characteristics and prognostic factors of inpatient mortality