文章：

血清游离轻链升高与慢性淋巴细胞白血病及单克隆B淋巴细胞增多症的关联

Association of elevated serumfree light chains with chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis

原文发布日期：2019-08-05

DOI: 10.1038/s41408-019-0220-x

类型: Article

开放获取: 是

英文摘要：

Chronic lymphocytic leukemia (CLL) and its precursor, monoclonal B-cell lymphocytosis (MBL), are heritable. Serumfree light-chain (sFLC) measures are a prognostic factor for CLL, but their role in susceptibility to CLL is not clear. We investigated differences between sFLC measurements in pre-treatment serum from five groups to inform the association of sFLC with familial and sporadic CLL: (1) familial CLL (n = 154), (2) sporadic CLL (n = 302), (3) familial MBL (n = 87), (4) unaffected first-degree relatives from CLL/MBL families (n = 263), and (5) reference population (n = 15,396). The percent of individuals having elevated monoclonal and polyclonal sFLCs was compared using age-stratified and age- and sex-adjusted logistic regression models. In age groups >50 years, monoclonal sFLC elevations were increased in sporadic and familial CLL cases compared to the reference population (p’s < 0.05). However, there were no statistically significant differences in sFLC monoclonal or polyclonal elevations between familial and sporadic CLL cases (p’s > 0.05). Unaffected relatives and MBL cases from CLL/MBL families, ages >60 years, showed elevated monoclonal sFLC, compared to the reference population (p’s < 0.05). This is the first study to demonstrate monoclonal sFLC elevations in CLL cases compared to controls. Monoclonal sFLC levels may provide additional risk information in relatives of CLL probands.
 

摘要翻译： 

慢性淋巴细胞白血病（CLL）及其前体——单克隆B细胞淋巴细胞增多症（MBL）具有遗传性。血清游离轻链（sFLC）检测是CLL的预后指标，但其在CLL易感性中的作用尚不明确。我们通过分析五组人群治疗前血清的sFLC测量值差异，探讨sFLC与家族性和散发性CLL的关联：（1）家族性CLL（n=154）；（2）散发性CLL（n=302）；（3）家族性MBL（n=87）；（4）CLL/MBL家族中未受累的一级亲属（n=263）；（5）参照人群（n=15,396）。采用年龄分层及经年龄、性别调整的逻辑回归模型，比较各组单克隆性与多克隆性sFLC升高者的百分比。在年龄＞50岁的人群中，散发性与家族性CLL患者的单克隆sFLC升高比例均显著高于参照人群（P值均＜0.05）。但家族性与散发性CLL病例间的单克隆或多克隆sFLC升高无统计学差异（P值均＞0.05）。在年龄＞60岁的CLL/MBL家族成员中，未受累亲属及MBL患者的单克隆sFLC水平均高于参照人群（P值均＜0.05）。本研究首次证实CLL患者存在相较于对照组的单克隆sFLC升高现象。单克隆sFLC水平或可为CLL先证者亲属提供额外的风险信息。

原文链接：

Association of elevated serumfree light chains with chronic lymphocytic leukemia and monoclonal B-cell lymphocytosis