文章：

在多发性骨髓瘤中，经皮椎体成形术和球囊后凸成形术骨水泥强化治疗椎体压缩性骨折的作用：国际骨髓瘤工作组（IMWG）共识声明

The role of cement augmentation with percutaneous vertebroplasty and balloon kyphoplasty for the treatment of vertebral compression fractures in multiple myeloma: a consensus statement from the International Myeloma Working Group (IMWG)

原文发布日期：2019-02-26

DOI: 10.1038/s41408-019-0187-7

类型: Article

开放获取: 是

英文摘要：

Multiple myeloma (MM) represents approximately 15% of haematological malignancies and most of the patients present with bone involvement. Focal or diffuse spinal osteolysis may result in significant morbidity by causing painful progressive vertebral compression fractures (VCFs) and deformities. Advances in the systemic treatment of myeloma have achieved high response rates and prolonged the survival significantly. Early diagnosis and management of skeletal events contribute to improving the prognosis and quality of life of MM patients. The management of patients with significant pain due to VCFs in the acute phase is not standardised. While some patients are successfully treated conservatively, and pain relief is achieved within a few weeks, a large percentage has disabling pain and morbidity and hence they are considered for surgical intervention. Balloon kyphoplasty and percutaneous vertebroplasty are minimally invasive procedures which have been shown to relieve pain and restore function. Despite increasing positive evidence for the use of these procedures, the indications, timing, efficacy, safety and their role in the treatment algorithm of myeloma spinal disease are yet to be elucidated. This paper reports an update of the consensus statement from the International Myeloma Working Group on the role of cement augmentation in myeloma patients with VCFs.

摘要翻译： 

多发性骨髓瘤约占血液系统恶性肿瘤的15%，多数患者伴有骨骼受累。局灶性或弥漫性脊柱骨溶解可能引发疼痛性进行性椎体压缩性骨折和畸形，导致严重病态。骨髓瘤全身治疗的进展已实现高缓解率并显著延长生存期。早期诊断和处理骨骼事件有助于改善多发性骨髓瘤患者的预后和生活质量。急性期因椎体压缩性骨折导致剧烈疼痛患者的治疗方案尚未标准化。虽然部分患者通过保守治疗成功缓解疼痛，但仍有相当比例患者存在致残性疼痛和并发症，因此需考虑手术干预。球囊后凸成形术和经皮椎体成形术作为微创术式，已被证实可有效缓解疼痛并恢复功能。尽管这些术式的积极证据日益增多，但其在骨髓瘤脊柱病变治疗流程中的适应证、时机选择、疗效、安全性及作用仍有待阐明。本文报告国际骨髓瘤工作组关于骨水泥增强术在伴椎体压缩性骨折的骨髓瘤患者中作用的共识声明更新。

原文链接：

The role of cement augmentation with percutaneous vertebroplasty and balloon kyphoplasty for the treatment of vertebral compression fractures in multiple myeloma: a consensus statement from the International Myeloma Working Group (IMWG)