文章：

多发性骨髓瘤健康差异的生物学决定因素

Biological determinants of health disparities in multiple myeloma

原文发布日期：2018-08-28

DOI: 10.1038/s41408-018-0118-z

类型: Review Article

开放获取: 是

英文摘要：

Multiple myeloma is a rare plasma cell cancer, and incidence rates among patients of African descent are about twice those among patients of European descent. Rates of multiple myeloma vary among different populations, but the reasons for the racial disparities in multiple myeloma are largely unknown. Epidemiology has identified risk factors for multiple myeloma including race, advanced age, gender, family history, and exposure to different genetic toxins including radiation. Race and ancestry play a large role in predicting the risk for multiple myeloma, yet there exists a paucity of literature that explores the molecular contribution of race and ancestry to disease. In this review, we describe the relevant literature that describes the observed racial differences according to distinct tumor immunobiological and ancestral differences in populations.

摘要翻译： 

多发性骨髓瘤是一种罕见的浆细胞恶性肿瘤，非洲裔患者的发病率约为欧洲裔患者的两倍。该疾病在不同人群中的发病率存在差异，但种族间差异的原因在很大程度上尚不明确。流行病学研究已确定的风险因素包括种族、高龄、男性性别、家族史以及接触辐射等不同遗传毒素。种族与祖源在预测多发性骨髓瘤风险中起着重要作用，然而探讨种族和祖源对疾病分子贡献的文献仍较为匮乏。本篇综述将依据不同人群的肿瘤免疫生物学特征及祖源差异，对描述已观察到的种族差异的相关文献进行阐述。

原文链接：

Biological determinants of health disparities in multiple myeloma