文章：

12372名10–49岁人群中多发性骨髓瘤前驱状态——意义未明单克隆丙种球蛋白病的患病率：基于国家健康与营养调查的人群研究

Prevalence of myeloma precursor state monoclonal gammopathy of undetermined significance in 12372 individuals 10–49 years old: a population-based study from the National Health and Nutrition Examination Survey

原文发布日期：2017-10-20

DOI: 10.1038/bcj.2017.97

类型: Original Article

开放获取: 是

英文摘要：

We studied the prevalence of monoclonal gammopathy of undetermined significance (MGUS) in younger individuals, age 10–49 years, using samples from the National Health and Nutritional Examination Survey (NHANES) III. NHANES prevalence rates were standardized to the 2000 US total population. Among 12 372 individuals (4073 blacks, 4146 Mexican-Americans, 3595 whites, and 558 others), MGUS was identified in 63 persons (0.34%, 95% CI 0.23–0.50). The prevalence of MGUS was significantly higher in blacks (0.88%, 95% CI 0.62–1.26) compared with whites (0.22%, 95% CI 0.11–0.45), P=0.001. The prevalence of MGUS in Mexican-Americans was at an intermediate level (0.41%, 95% CI 0.23–0.73). The disparity in prevalence of MGUS between blacks and whites was most striking in the 40–49 age-group; 3.26% (95% CI 2.04–5.18) versus 0.53% (95% CI 0.20–1.37), P=0.0013. There was a trend to earlier age of onset of MGUS in blacks compared with whites. MGUS was seen in only two persons in the 10–19 age-group (both Mexican-American), and in three persons in the 20–29-year age-group (all of whom were black). In persons less than 50 years of age, MGUS is significantly more prevalent, with up to 10 years earlier age of onset, in blacks compared with whites.

摘要翻译： 

我们利用美国国家健康与营养调查（NHANES）III的样本，研究了10-49岁较年轻人群中意义未明的单克隆丙种球蛋白病（MGUS）的患病率。NHANES患病率数据已按2000年美国总人口进行标准化。在12,372名研究对象（包括4073名黑人、4146名墨西哥裔美国人、3595名白人和558名其他族裔）中，共发现63例MGUS患者（患病率0.34%，95%置信区间0.23-0.50）。黑人群体MGUS患病率（0.88%，95%置信区间0.62-1.26）显著高于白人群体（0.22%，95%置信区间0.11-0.45）（P=0.001）。墨西哥裔美国人患病率处于中间水平（0.41%，95%置信区间0.23-0.73）。黑人与白人之间的患病率差异在40-49岁年龄组最为显著，分别为3.26%（95%置信区间2.04-5.18）和0.53%（95%置信区间0.20-1.37）（P=0.0013）。与白人相比，黑人MGUS发病年龄有提前趋势。10-19岁年龄组仅发现两例患者（均为墨西哥裔美国人），20-29岁年龄组发现三例患者（均为黑人）。在50岁以下人群中，黑人不仅MGUS患病率显著更高，且发病时间较白人提前长达10年。

原文链接：

Prevalence of myeloma precursor state monoclonal gammopathy of undetermined significance in 12372 individuals 10–49 years old: a population-based study from the National Health and Nutrition Examination Survey