文章：

剂量密集且强度降低的Total Therapy 5方案用于基因表达谱定义的高危多发性骨髓瘤

Dose-dense and less dose-intense Total Therapy 5 for gene expression profiling-defined high-risk multiple myeloma

原文发布日期：2016-07-29

DOI: 10.1038/bcj.2016.64

类型: Original Article

开放获取: 是

英文摘要：

Multiple myeloma (MM) is a heterogeneous disease with high-risk patients progressing rapidly despite treatment. Various definitions of high-risk MM are used and we reported that gene expression profile (GEP)-defined high risk was a major predictor of relapse. In spite of our best efforts, the majority of GEP70 high-risk patients relapse and we have noted higher relapse rates during drug-free intervals. This prompted us to explore the concept of less intense drug dosing with shorter intervals between courses with the aim of preventing inter-course relapse. Here we report the outcome of the Total Therapy 5 trial, where this concept was tested. This regimen effectively reduced early mortality and relapse but failed to improve progression-free survival and overall survival due to relapse early during maintenance.

摘要翻译： 

多发性骨髓瘤（MM）是一种异质性疾病，高危患者尽管接受治疗仍会快速进展。目前存在多种高危多发性骨髓瘤的定义，我们曾报道基因表达谱（GEP）定义的高危是复发的主要预测因素。尽管我们已竭尽全力，大多数GEP70高危患者仍会复发，并且我们注意到在无药间隔期复发率更高。这促使我们探索降低药物剂量、缩短疗程间隔的治疗方案，旨在预防疗程间期的复发。本文报告了验证这一理念的Total Therapy 5试验结果。该方案有效降低了早期死亡率和复发率，但由于维持治疗早期出现的复发，未能改善无进展生存期和总生存期。

原文链接：

Dose-dense and less dose-intense Total Therapy 5 for gene expression profiling-defined high-risk multiple myeloma